Opportunity Information: Apply for RFA HL 17 026
Revision Applications for Regenerative Medicine Innovation Projects (RMIP) (UM1), RFA-HL-17-026, is a one-time NIH funding opportunity, developed with participation from multiple NIH Institutes and Centers and the U.S. Food and Drug Administration (FDA), aimed specifically at investigators who already hold an active UM1 cooperative agreement in this regenerative medicine space. The core purpose is not to start a brand-new standalone project, but to allow a "competing revision" to an existing, currently funded UM1 award. In practical terms, that means applicants are requesting additional funds during an active budget period so they can expand the approved scope, add work that was not originally supported, or meaningfully extend the research protocol in ways that strengthen the project and accelerate progress toward clinically relevant outcomes.
Scientifically, the FOA is centered on clinical research studies that advance regenerative medicine approaches using adult stem cells. The emphasis is on innovation that tackles problems the field widely recognizes as bottlenecks to delivering safe and effective regenerative medicine therapies. Rather than supporting incremental additions, the revision is expected to propose concrete solutions to translational and development challenges that routinely slow the path from promising biology to a therapy that can be responsibly tested, evaluated, and potentially brought to patients.
A major priority in this announcement is work that directly supports product development in ways that matter for regulatory submissions, reflecting the FDA partnership and the real-world requirements of moving a cellular therapy forward. The FOA highlights needs such as better tools, improved methods, and more robust standards, along with applied science efforts that sharpen how the field understands and evaluates key dimensions of regenerative medicine products. Those dimensions include manufacturing (how the product is made and controlled), quality (consistency, identity, purity, potency), safety (risk assessment and monitoring), and effectiveness (evidence the therapy performs as intended in a clinically meaningful way). The overall message is that revisions should help close gaps between academic innovation and the kind of validated, well-characterized evidence packages that regulators expect when therapies progress toward clinical testing and eventual approval pathways.
From an administrative and funding standpoint, this opportunity is issued by the U.S. Department of Health and Human Services through the NIH and uses a Cooperative Agreement mechanism (UM1). The cooperative agreement structure generally implies substantial federal scientific or programmatic involvement compared to a standard research project grant, which fits the translational and development-oriented nature of the program. The listing includes multiple CFDA program numbers (93.121, 93.173, 93.233, 93.242, 93.286, 93.350, 93.837, 93.838, 93.839, 93.840, 93.846, 93.847, 93.853, 93.855, 93.856, 93.866, 93.867), reflecting participation across NIH components.
Eligibility is broad at the institution level, spanning many organization types, but it is constrained in practice by the requirement that the applicant be an investigator with an active UM1 award that fits the program. Eligible applicant organizations include state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (excluding higher education institutions in those categories); for-profit organizations other than small businesses; small businesses; and other entities as described in the FOA text. This breadth signals that the program is open to a wide range of research-performing settings, including academic, nonprofit, government, and industry environments, as long as the underlying UM1 project context and revision requirements are met.
Key dates and funding parameters in the source data indicate the FOA was created on April 28, 2017, with an original closing date of June 26, 2017, suggesting a defined submission window rather than an ongoing, annually repeating opportunity. The expected number of awards was six, and the listed award ceiling was $324,500, which can be interpreted as an upper bound for additional support provided through the revision per award under this announcement (subject to the detailed budget rules and allowable costs specified in the full FOA).
Overall, RFA-HL-17-026 is best understood as a targeted expansion mechanism for existing UM1 regenerative medicine projects using adult stem cells, designed to fund high-impact additions that resolve translational and regulatory-relevant development challenges. The intended outcome is to strengthen the evidence base, tools, and standards needed to evaluate and advance regenerative medicine products with greater confidence in their manufacturing quality, safety profile, and potential clinical effectiveness.Apply for RFA HL 17 026
- The Department of Health and Human Services, National Institutes of Health in the food and nutrition, health sector is offering a public funding opportunity titled "Revision Applications for Regenerative Medicine Innovation Projects (RMIP) (UM1)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121, 93.173, 93.233, 93.242, 93.286, 93.350, 93.837, 93.838, 93.839, 93.840, 93.846, 93.847, 93.853, 93.855, 93.856, 93.866, 93.867.
- This funding opportunity was created on Apr 28, 2017.
- Applicants must submit their applications by Jun 26, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $324,500.00 in funding.
- The number of recipients for this funding is limited to 6 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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Applicants who have applied for this opportunity (RFA HL 17 026) also looked into and applied for these:
| Funding Opportunity |
|---|
| Revision Applications for Regenerative Medicine Innovation Projects (RMIP) (U54) Apply for RFA HL 17 025 Funding Number: RFA HL 17 025 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $324,500 |
| Revision Applications for Regenerative Medicine Innovation Projects (RMIP) (R01) Apply for RFA HL 17 029 Funding Number: RFA HL 17 029 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $324,500 |
| Revision Applications for Regenerative Medicine Innovation Projects (RMIP) (P50) Apply for RFA HL 17 032 Funding Number: RFA HL 17 032 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $324,500 |
| Revision Applications for Regenerative Medicine Innovation Projects (RMIP) (R24) Apply for RFA HL 17 030 Funding Number: RFA HL 17 030 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $324,500 |
| Revision Applications for Regenerative Medicine Innovation Projects (RMIP) (U01) Apply for RFA HL 17 034 Funding Number: RFA HL 17 034 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $324,500 |
| Revision Applications for Regenerative Medicine Innovation Projects (RMIP) (P41) Apply for RFA HL 17 033 Funding Number: RFA HL 17 033 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $324,500 |
| Cystic Fibrosis Research and Translation Center (P30) Apply for RFA DK 17 007 Funding Number: RFA DK 17 007 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $750,000 |
| NIDDK Information Network Coordinating Unit: dkNET-CU (U24) Apply for RFA DK 17 010 Funding Number: RFA DK 17 010 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $635,000 |
| Limited Competition for the Continuation of the Drug Induced Liver Injury Network Data Coordinating Center (U24) Apply for RFA DK 17 510 Funding Number: RFA DK 17 510 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $900,000 |
| Limited Competition for the Continuation of the Drug Induced Liver Injury Network (DILIN) Clinical Centers (U01) Apply for RFA DK 17 509 Funding Number: RFA DK 17 509 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $250,000 |
| Chronic Kidney Disease in Children Central Biochemistry Laboratory (U24) Apply for RFA DK 17 034 Funding Number: RFA DK 17 034 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $250,000 |
| Catalyst Award in Diabetes, Endocrinology and Metabolic Diseases (DP1- Clinical Trial Not Allowed) Apply for RFA DK 17 011 Funding Number: RFA DK 17 011 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $500,000 |
| NIDDK Partnerships with Professional Societies to Enhance Scientific Workforce Diversity and Promote Scientific Leadership (R25) Apply for RFA DK 17 015 Funding Number: RFA DK 17 015 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $135,000 |
| Diabetic Foot Consortium - Clinical Research Units (U01) Apply for RFA DK 17 014 Funding Number: RFA DK 17 014 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $275,000 |
| Lymphatics in Health and Disease in the Digestive System (R01 - Clinical Trials Not Allowed) Apply for RFA DK 17 016 Funding Number: RFA DK 17 016 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $499,999 |
| Multidisciplinary Urologic Research (KURe) Career Development Program (K12 Clinical Trial Optional) Apply for RFA DK 17 012 Funding Number: RFA DK 17 012 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $600,000 |
| George M. O'Brien Urology Cooperative Research Centers Program (U54-Clinical Trial Optional) Apply for RFA DK 17 013 Funding Number: RFA DK 17 013 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $1,000,000 |
| Silvio O. Conte Digestive Diseases Research Core Centers (P30 Clinical Trial Optional) Apply for RFA DK 18 001 Funding Number: RFA DK 18 001 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $750,000 |
| Funding For Collaborative Clinical Research In Type 1 Diabetes: Living Biobank (R01 Clinical Trial Optional) Apply for RFA DK 17 032 Funding Number: RFA DK 17 032 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $600,000 |
| Elucidating the Effect of Glycemic Excursions on Patient Well-being and Cognitive Status in People with Type 1 Diabetes (T1D) (R01 Clinical Trial Optional) Apply for RFA DK 18 003 Funding Number: RFA DK 18 003 Agency: Department of Health and Human Services, National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $500,000 |
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