Opportunity Information: Apply for RFA IP 19 002
This funding opportunity, titled "Increasing Influenza and Tdap Vaccination of Pregnant Women in Obstetric/Gynecologic Practices in Large Health Systems through Quality Improvement Interventions," is a CDC cooperative agreement designed to support a randomized controlled trial focused on improving adult immunization practices in prenatal care settings. The core purpose is to test whether structured quality improvement interventions can meaningfully raise vaccination coverage for two key maternal vaccines, seasonal influenza and Tdap, among pregnant patients receiving care in obstetric/gynecologic practices. The work is intended to take place inside a large health system and must include at least two OB/GYN practices that already stock both influenza and Tdap vaccines, since the interventions are aimed at improving delivery and uptake rather than solving vaccine access through stocking alone.
The project is framed as an effectiveness evaluation using an RCT design, meaning applicants are expected to implement and rigorously assess one or more quality improvement strategies under real-world conditions and compare outcomes between study arms. In practical terms, the trial would likely examine how changes in clinic workflow, provider prompts, standing orders, staff training, performance feedback, patient reminders, or electronic health record-based interventions affect whether pregnant patients receive recommended vaccinations during prenatal visits. The emphasis on a randomized design signals that the CDC is looking for strong causal evidence about what works best in OB/GYN practice environments, not just descriptive reporting or simple before-and-after comparisons.
The eligible applicant pool is broad and includes governmental public health entities and a wide range of partner organizations that commonly participate in applied public health research and healthcare improvement work. Eligible applicants include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; federally recognized tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; and nonprofit organizations both with and without 501(c)(3) status (excluding higher education institutions when specified by category). The listing also includes an "Others" category with additional eligibility details referenced in the full announcement, which typically covers additional types of entities that can demonstrate the capacity to conduct the required work in collaboration with a large health system and applicable public health jurisdictions.
From an administrative standpoint, the opportunity is categorized as discretionary funding and uses a cooperative agreement mechanism, which generally means the CDC expects substantial involvement during the project period. Cooperative agreements often include technical assistance, collaboration on study design and evaluation, shared decisions about major project elements, and ongoing reporting requirements. The funding activity category is health, and it is associated with CFDA number 93.185. The opportunity was created on October 31, 2018, with an original application deadline of January 29, 2019, and applications were required to be submitted electronically by 5:00 p.m. Eastern Time on the due date.
In terms of scale, the maximum award amount listed is $500,000, and the CDC anticipated making two awards. This suggests a relatively focused set of funded projects, likely selected for strong study design, access to appropriate clinical sites and patient populations, and the ability to implement and measure quality improvement interventions in a way that produces credible, generalizable findings. Overall, the opportunity is structured to generate high-quality evidence on how large health systems and OB/GYN practices can improve maternal vaccination delivery, with the public health goal of increasing protection for pregnant women and their infants against influenza and pertussis through better clinical implementation of existing vaccine recommendations.Apply for RFA IP 19 002
- The Department of Health and Human Services, Centers for Disease Control and Prevention - ERA in the health sector is offering a public funding opportunity titled "Increasing Influenza and Tdap Vaccination of Pregnant Women in Obstetric/Gynecologic Practices in Large Health Systems through Quality Improvement Interventions" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.185.
- This funding opportunity was created on Oct 31, 2018.
- Applicants must submit their applications by Jan 29, 2019 Electronically submitted applications must be submitted no later than 500 p.m., ET, on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- The number of recipients for this funding is limited to 2 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Others (see text field entitled Additional Information on Eligibility for clarification).
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Frequently Asked Questions (FAQs)
What is the title of this funding opportunity?
The funding opportunity is titled "Increasing Influenza and Tdap Vaccination of Pregnant Women in Obstetric/Gynecologic Practices in Large Health Systems through Quality Improvement Interventions."
Who is offering this grant opportunity?
This opportunity is offered by the Centers for Disease Control and Prevention (CDC) as a cooperative agreement.
What is the main purpose of the project?
The purpose is to test whether structured quality improvement interventions can meaningfully increase vaccination coverage for two recommended maternal vaccines (seasonal influenza and Tdap) among pregnant patients receiving prenatal care in OB/GYN practices.
Which vaccines are the focus of this project?
The project focuses on increasing uptake of seasonal influenza vaccine and Tdap vaccine among pregnant women.
What type of study design is expected?
The project is framed as an effectiveness evaluation using a randomized controlled trial (RCT) design. Applicants are expected to implement and rigorously assess one or more quality improvement strategies and compare outcomes between study arms.
Why does the opportunity require a randomized controlled trial (RCT)?
The emphasis on randomization indicates the CDC is seeking strong causal evidence about what quality improvement strategies work best in OB/GYN practice environments, rather than relying on descriptive results or simple before-and-after comparisons.
Where is the work expected to take place?
The work is intended to take place inside a large health system and within obstetric/gynecologic practices that provide prenatal care.
How many OB/GYN practices must be included?
The project must include at least two OB/GYN practices.
Do participating practices need to stock vaccines?
Yes. The participating OB/GYN practices must already stock both influenza and Tdap vaccines. The interventions are intended to improve delivery and uptake, not to solve vaccine access through stocking alone.
What kinds of quality improvement interventions are implied by the announcement?
Examples suggested by the description include clinic workflow changes, provider prompts, standing orders, staff training, performance feedback, patient reminders, and electronic health record (EHR)-based interventions.
Is this opportunity focused on adult immunization or pediatric immunization?
It is focused on adult immunization practices in prenatal care settings, specifically vaccination of pregnant patients.
What is the funding mechanism?
The mechanism is a cooperative agreement. This generally means CDC expects substantial involvement during the project period, such as collaboration, technical assistance, and ongoing reporting.
What does it mean that this is a cooperative agreement?
Based on the description, cooperative agreements commonly involve CDC engagement in areas like technical assistance, collaboration on study design and evaluation, shared decisions about major project elements, and ongoing reporting requirements.
How is this opportunity categorized in terms of funding type?
It is categorized as discretionary funding.
What is the funding activity category?
The funding activity category is health.
What is the CFDA number associated with this opportunity?
The opportunity is associated with CFDA number 93.185.
Who is eligible to apply?
The eligible applicant pool is broad and includes governmental public health entities and a wide range of partner organizations. Listed eligible applicants include:
- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and state-controlled institutions of higher education
- Federally recognized tribal governments
- Other tribal organizations
- Public housing authorities/Indian housing authorities
- Nonprofit organizations with 501(c)(3) status (excluding higher education institutions when specified by category)
- Nonprofit organizations without 501(c)(3) status (excluding higher education institutions when specified by category)
- An "Others" category with additional eligibility details referenced in the full announcement
What is meant by the "Others" eligibility category?
The description notes an "Others" category with additional eligibility details referenced in the full announcement. This typically includes additional types of entities that can demonstrate capacity to conduct the required work in collaboration with a large health system and applicable public health jurisdictions.
How many awards did CDC anticipate making?
The CDC anticipated making two awards.
What is the maximum award amount?
The maximum award amount listed is $500,000.
What does the expected number of awards suggest about competitiveness or project scale?
With a maximum award of $500,000 and only two anticipated awards, the opportunity appears designed for a relatively small number of highly qualified projects with strong study designs, access to appropriate clinical sites and patient populations, and the ability to implement and measure quality improvement interventions credibly.
When was the opportunity created?
The opportunity was created on October 31, 2018.
What was the application deadline?
The original application deadline was January 29, 2019.
How were applications required to be submitted?
Applications were required to be submitted electronically.
What time were applications due on the deadline date?
Applications were required to be submitted by 5:00 p.m. Eastern Time on the due date.
What is the public health goal behind this opportunity?
The public health goal is to increase protection for pregnant women and their infants against influenza and pertussis by improving clinical implementation of existing maternal vaccine recommendations in OB/GYN prenatal care settings.
What outcomes is the project trying to improve?
The core outcome is higher vaccination coverage for influenza and Tdap among pregnant patients in participating OB/GYN practices, measured in a way that supports comparison between randomized study arms.
Does this opportunity focus on vaccine supply or vaccine delivery processes?
It focuses on vaccine delivery and uptake processes within practices that already stock both vaccines, rather than addressing vaccine access through stocking.
What kinds of organizations are likely to be well-positioned for this project?
Organizations that can collaborate with a large health system, recruit at least two OB/GYN practices that stock influenza and Tdap vaccines, and implement and evaluate quality improvement interventions under an RCT design are aligned with the project expectations described.
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