Opportunity Information: Apply for RFA DA 25 061
The HEAL Initiative: JCOIN Phase II Economic Research Resource Center (U24 Clinical Trial Optional) opportunity (RFA-DA-25-061) is a National Institutes of Health (NIH) cooperative agreement intended to strengthen the economic research and analytic support capacity for the Justice Community Opioid Innovation Network (JCOIN). JCOIN sits within the larger HEAL (Helping to End Addiction Long-term) Initiative and is designed to speed the translation of research into practice inside criminal-legal settings, where opioid use disorder (OUD) and other substance use disorders (SUD) are highly prevalent. The program is grounded in a well-documented risk pattern: many people entering jail or prison face acute opioid withdrawal during incarceration, and after release they face sharply elevated overdose risk, particularly when they did not receive medications for opioid use disorder (MOUD) while detained. Because most U.S. jails still do not provide MOUD consistently or to everyone who could benefit, JCOIN supports a coordinated portfolio of studies that test real-world strategies to expand access to evidence-based OUD treatment in justice settings.
At a practical level, the grant supports an Economic Research Resource Center that can serve JCOIN Phase II by providing rigorous health economics and related analytic expertise across multiple studies. JCOIN projects commonly use hybrid effectiveness-implementation trial designs, meaning they evaluate both whether an intervention works and how to implement it in complex systems like jails, prisons, probation, parole, and community reentry services. An economic resource center in this context is meant to help the network answer questions that decision-makers routinely ask but that are often underdeveloped in implementation research, such as what it costs to start and sustain MOUD programs in correctional facilities, what resources are required to scale, what cost offsets might occur (for example, reduced emergency care or reincarceration), and how to evaluate economic value across different jurisdictions with different staffing models, vendor contracts, and healthcare financing arrangements. The "U24 Clinical Trial Optional" structure signals that the award can include clinical trial activity if needed, but it is not required; the emphasis is on coordinated infrastructure and support functions that elevate the quality, comparability, and usefulness of economic analyses across the JCOIN portfolio.
The funding instrument is a cooperative agreement, which typically means NIH will have substantial involvement beyond a standard grant, often through collaboration on priorities, milestones, and coordination across the network. The activity category is listed under education and health, and the CFDA number is 93.279. The opportunity was created on 2024-06-06, with an original closing date of 2025-01-22. While an award ceiling and expected number of awards are not specified in the provided source data, applicants generally should be prepared for a competitive, network-facing award that requires strong coordination skills, demonstrated expertise in economic evaluation in healthcare and justice settings, and the ability to support multiple parallel projects with consistent methods and reporting.
Eligibility is broad across public, private, nonprofit, and certain for-profit entities, reflecting the cross-sector nature of criminal-legal and healthcare collaborations. Eligible applicants include state, county, and city or township governments; special district governments; independent school districts; public housing authorities/Indian housing authorities; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; other Native American tribal organizations (other than federally recognized tribal governments); nonprofits with and without 501(c)(3) status (other than higher education institutions); for-profit organizations other than small businesses; small businesses; and other organizations. The announcement also highlights additional eligible applicant types such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), faith-based or community-based organizations, Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), Indian/Native American tribal governments other than federally recognized, regional organizations, Tribally Controlled Colleges and Universities (TCCUs), and U.S. territories or possessions. Foreign organizations (non-domestic, non-U.S. entities) are not eligible to apply, and non-domestic components of U.S. organizations are not eligible to apply; however, foreign components are allowed as defined in the NIH Grants Policy Statement, which generally means a U.S.-based applicant may include certain well-justified foreign elements as part of the project if permitted under NIH policy and aligned with program goals.
Overall, this opportunity is positioned as the HEAL initiative’s primary effort centered on justice-involved populations and criminal-legal systems, with the explicit goal of increasing delivery of and access to MOUD. By funding an economic research resource center, NIH is signaling that implementation success is not only a matter of clinical effectiveness, but also of cost, financing, sustainability, and the operational realities faced by jails and community supervision agencies. The intended outcome is more actionable evidence for policymakers, correctional leaders, healthcare partners, and communities trying to reduce overdose deaths and improve continuity of OUD care during incarceration and after release.Apply for RFA DA 25 061
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "HEAL Initiative: JCOIN Phase II Economic Research Resource Center (U24 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279.
- This funding opportunity was created on 2024-06-06.
- Applicants must submit their applications by 2025-01-22. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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FAQs: HEAL Initiative JCOIN Phase II Economic Research Resource Center (RFA-DA-25-061)
What is this funding opportunity?
This opportunity funds an Economic Research Resource Center to support Justice Community Opioid Innovation Network (JCOIN) Phase II. It is a National Institutes of Health (NIH) cooperative agreement under the HEAL (Helping to End Addiction Long-term) Initiative, focused on improving economic research and analytic support across JCOIN studies in criminal-legal settings.
What is JCOIN and how does it relate to the HEAL Initiative?
JCOIN is a HEAL Initiative program designed to speed the translation of research into practice inside criminal-legal settings (such as jails, prisons, probation, parole, and reentry services). It supports a coordinated set of studies aimed at expanding access to evidence-based treatment for opioid use disorder (OUD), including medications for opioid use disorder (MOUD).
What problem is this program trying to address?
The program is grounded in a documented risk pattern for justice-involved people: many experience acute opioid withdrawal during incarceration, and overdose risk increases sharply after release, especially when MOUD was not provided during detention. Since many U.S. jails do not provide MOUD consistently or to everyone who could benefit, JCOIN focuses on practical strategies to expand MOUD access in justice settings.
What is being funded: a research study or a support center?
The primary focus is a coordinated support center (an Economic Research Resource Center) that provides rigorous health economics and related analytic expertise across multiple JCOIN projects. The intent is to strengthen infrastructure and analytic capacity network-wide rather than fund a single standalone intervention study.
What is an Economic Research Resource Center in the JCOIN context?
In this context, the center is meant to provide economic research and analytic support that helps JCOIN studies answer real-world decision-maker questions. Examples include estimating costs to start and sustain MOUD programs in correctional facilities, resources needed to scale, potential cost offsets (like reduced emergency care or reincarceration), and comparable approaches to evaluating economic value across jurisdictions with different operational and financing arrangements.
What kinds of analyses or questions would this center help with?
Based on the opportunity description, support may include methods and analyses related to costs, financing, sustainability, and economic value of MOUD implementation strategies, including:
- Costs to start and maintain MOUD programs in jails/prisons
- Resources needed for scaling across different sites and systems
- Potential cost offsets (for example, fewer emergency care visits or less reincarceration)
- Comparability of economic findings across jurisdictions with different staffing, vendors, contracts, and healthcare financing models
What types of study designs does JCOIN commonly use?
JCOIN projects commonly use hybrid effectiveness-implementation trial designs. These designs evaluate both whether an intervention works and how to implement it in complex real-world systems such as correctional facilities and community supervision/reentry services.
Does the award require a clinical trial?
No. The opportunity is labeled "U24 Clinical Trial Optional," meaning clinical trial activity can be included if needed, but it is not required. The emphasis is on coordinated infrastructure and support functions that improve the quality and usefulness of economic analyses across the JCOIN portfolio.
What does it mean that this is a cooperative agreement?
A cooperative agreement indicates NIH will likely have substantial involvement beyond a standard grant. In practice, that usually means collaboration on priorities, milestones, and coordination across the network rather than a fully investigator-driven award with minimal agency involvement.
Who is the funder?
The funder is the National Institutes of Health (NIH), and the opportunity sits within the HEAL Initiative. The resource center is intended to support the Justice Community Opioid Innovation Network (JCOIN).
What is the opportunity number and title?
The opportunity is RFA-DA-25-061, titled "The HEAL Initiative: JCOIN Phase II Economic Research Resource Center (U24 Clinical Trial Optional)."
What is the CFDA number listed for this opportunity?
The CFDA number provided is 93.279.
What is the activity category for this opportunity?
The activity category is listed under education and health.
When was this opportunity created and when did it close?
The opportunity was created on 2024-06-06. The original closing date listed is 2025-01-22.
Is there an award ceiling or a stated number of expected awards?
No award ceiling and no expected number of awards are specified in the provided information.
What kinds of organizations are eligible to apply?
Eligibility is broad and includes many public, private, nonprofit, and for-profit entity types. Eligible applicants include:
- State, county, and city or township governments
- Special district governments
- Independent school districts
- Public housing authorities/Indian housing authorities
- Public and state-controlled institutions of higher education
- Private institutions of higher education
- Federally recognized Native American tribal governments
- Other Native American tribal organizations (other than federally recognized tribal governments)
- Nonprofits with and without 501(c)(3) status (other than higher education institutions)
- For-profit organizations other than small businesses
- Small businesses
- Other organizations
Are specific institution types explicitly highlighted as eligible?
Yes. The announcement highlights additional eligible applicant types including Alaska Native and Native Hawaiian Serving Institutions, AANAPISIs, faith-based or community-based organizations, Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), Indian/Native American tribal governments other than federally recognized, regional organizations, Tribally Controlled Colleges and Universities (TCCUs), and U.S. territories or possessions.
Are foreign organizations eligible to apply?
No. Foreign organizations (non-domestic, non-U.S. entities) are not eligible to apply, and non-domestic components of U.S. organizations are not eligible to apply.
Are foreign components allowed at all?
Yes. Foreign components are allowed as defined in the NIH Grants Policy Statement, meaning a U.S.-based applicant may include certain well-justified foreign elements as part of the project if permitted under NIH policy and aligned with the program goals.
What settings are most relevant to this program?
The program is explicitly focused on criminal-legal settings and related systems, including jails, prisons, probation, parole, and community reentry services, where OUD and other substance use disorders (SUD) are highly prevalent.
What is MOUD and why is it central to this opportunity?
MOUD refers to medications for opioid use disorder. This opportunity is centered on increasing delivery of and access to MOUD in justice settings because inconsistent MOUD availability during incarceration is linked to heightened overdose risk after release and poor continuity of care.
What is the intended impact of funding an economic resource center?
The intended impact is to produce more actionable evidence for policymakers, correctional leaders, healthcare partners, and communities. By strengthening economic and analytic capacity across JCOIN studies, NIH is emphasizing that implementation success depends not only on clinical effectiveness, but also on cost, financing, sustainability, and operational realities in correctional and community supervision systems.
What capabilities would a strong applicant likely need based on the description?
The description suggests applicants should be prepared for a competitive, network-facing award that requires strong coordination skills, demonstrated expertise in economic evaluation in healthcare and justice settings, and the ability to support multiple parallel projects with consistent methods and reporting.
Why does the opportunity emphasize comparability across jurisdictions?
JCOIN work spans different jurisdictions that may have different staffing models, vendor contracts, and healthcare financing arrangements. The economic resource center is meant to help ensure economic evaluations are rigorous and comparable across these differences so results are more useful for decision-making.
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