Opportunity Information: Apply for PAR 19 250
The National Institutes of Health (NIH) funding opportunity titled Environmental Influences on Aging: Effects of Extreme Weather and Disaster Events on Aging Populations (R01 Clinical Trial Optional) supports research that clarifies how extreme weather and disaster events affect older adults in real-world human populations. The central aim is to deepen scientific understanding of what happens to aging individuals before, during, and after events such as hurricanes, floods, wildfires, heat waves, severe storms, and other disasters, with particular attention to how these events shape health trajectories and aging processes over time. The announcement emphasizes that disasters are not only acute crises; they can also trigger longer-term biological, behavioral, and social changes that may accelerate decline, worsen chronic disease, or alter resilience and recovery among older people.
A key feature of this opportunity is its focus on population-based and human-subjects research, including but not limited to clinical trials (hence "clinical trial optional"). NIH is looking for studies that can unpack multiple, interacting pathways through which extreme events influence aging. These pathways explicitly include behavioral factors (for example, stress responses, medication adherence disruptions, sleep changes, nutrition, physical activity), biological processes (such as inflammation, cardiometabolic strain, immune function), and more specialized domains like epigenetic and genetic influences, neurological outcomes, and socioecological dynamics. In practice, this means proposed projects might examine how environmental shocks translate into measurable changes in cognition, mental health, functional status, disability, morbidity, and mortality, and why some groups of older adults experience disproportionate harm or slower recovery.
The FOA is paired with a companion funding opportunity (PAR-19-XXX) that targets basic mechanisms of aging using animal models. NIH frames the two announcements as complementary: human population studies can identify patterns, risk factors, and outcomes in actual disaster-exposed communities, while mechanistic animal research can help explain underlying causal pathways. The intention is that findings across the two tracks can be integrated to create a more complete picture, linking observed real-world impacts (for example, worsening frailty after displacement) to plausible mechanistic explanations (for example, stress-mediated biological aging). This integrated approach is meant to move the field toward actionable knowledge that can improve preparedness, response, and recovery strategies tailored to older adults.
The public health goal is strongly practical: to improve the health and well-being of older adults by generating evidence that can inform disaster planning and resilience building. This includes strengthening understanding of which interventions, policies, community supports, or healthcare system practices help older adults fare better during and after extreme events. The emphasis on preparedness, response, and recovery suggests NIH is interested not only in documenting harm, but also in identifying modifiable factors and opportunities to reduce risk, support continuity of care, and speed functional and psychological recovery.
This is an NIH discretionary grant using the R01 mechanism, which is commonly used for substantial research projects. The funding opportunity number is PAR 19 250, and the activity categories listed span education, environment, and health, reflecting the cross-cutting nature of the topic. Multiple CFDA numbers are associated with the opportunity (93.113, 93.307, 93.361, 93.866), indicating involvement or relevance across NIH programs connected to aging and health research.
Eligibility is broad across U.S.-based institutions and organizations that can carry out the work. Eligible applicants include state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; public housing authorities and Indian housing authorities; tribal organizations that are not federally recognized; nonprofits with or without 501(c)(3) status (outside higher education); for-profit organizations (other than small businesses); and small businesses. The announcement also highlights inclusion of institutions that serve underrepresented populations and community-focused organizations, such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities, Tribally Controlled Colleges and Universities, eligible federal agencies, faith-based or community-based organizations, regional organizations, and U.S. territories or possessions.
At the same time, there are clear restrictions on foreign involvement. Non-domestic (non-U.S.) entities and foreign institutions are not eligible to apply, non-domestic components of U.S. organizations are not eligible, and foreign components (as NIH defines them in its Grants Policy Statement) are not allowed. In other words, the supported work must be based within eligible U.S. organizational structures without foreign components as part of the project scope.
Administrative details included in the source indicate the opportunity was created on 2019-04-11, with an original closing date listed as 2021-03-08. The award ceiling and expected awards fields are not specified in the provided excerpt. Overall, the opportunity is geared toward rigorous, multidisciplinary research that connects environmental extremes and disasters to the short- and long-term realities of aging, with the expectation that results will translate into better protection and support for older adults facing increasingly frequent and severe climate- and disaster-related events.Apply for PAR 19 250
- The National Institutes of Health in the education, environment, health sector is offering a public funding opportunity titled "Environmental Influences on Aging: Effects of Extreme Weather and Disaster Events on Aging Populations (R01 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.307, 93.361, 93.866.
- This funding opportunity was created on 2019-04-11.
- Applicants must submit their applications by 2021-03-08. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Frequently Asked Questions (FAQs)
1) What is the title of this NIH funding opportunity?
The funding opportunity is titled Environmental Influences on Aging: Effects of Extreme Weather and Disaster Events on Aging Populations (R01 Clinical Trial Optional).
2) What is the funding opportunity number?
The funding opportunity number provided is PAR 19 250.
3) What type of grant mechanism is used?
This opportunity uses the NIH R01 mechanism, which is commonly used for substantial research projects.
4) What is the main purpose of this opportunity?
The main purpose is to support research that clarifies how extreme weather and disaster events affect older adults in real-world human populations, including what happens before, during, and after these events and how they shape health trajectories and aging processes over time.
5) What kinds of events are considered “extreme weather and disaster events” under this opportunity?
Examples listed include hurricanes, floods, wildfires, heat waves, severe storms, and other disaster events.
6) What does “Clinical Trial Optional” mean in this FOA?
It means the opportunity supports human-subjects research and may include clinical trials, but a clinical trial is not required. Projects can be clinical-trial or non-clinical-trial human research, as long as they align with the FOA’s goals.
7) What research focus is NIH emphasizing?
NIH emphasizes population-based and human-subjects research designed to unpack multiple, interacting pathways through which disasters and extreme weather influence aging outcomes.
8) What types of pathways or mechanisms are specifically mentioned?
The FOA explicitly highlights interacting pathways that can include:
- Behavioral factors (for example: stress responses, medication adherence disruptions, sleep changes, nutrition, physical activity)
- Biological processes (such as inflammation, cardiometabolic strain, immune function)
- Epigenetic and genetic influences
- Neurological outcomes
- Socioecological dynamics
9) What outcomes in older adults does NIH appear interested in?
The announcement points to measurable changes in outcomes such as cognition, mental health, functional status, disability, morbidity, and mortality, as well as differences in resilience and recovery after disaster exposure.
10) Does the FOA focus only on immediate disaster impacts?
No. NIH emphasizes that disasters are not only acute crises; they can also trigger longer-term biological, behavioral, and social changes that may accelerate decline, worsen chronic disease, or alter resilience and recovery among older adults.
11) Is there an emphasis on disparities or disproportionate impacts?
Yes. The FOA highlights the importance of understanding why some groups of older adults experience disproportionate harm or slower recovery following extreme weather or disaster events.
12) How is this FOA related to the companion opportunity mentioned?
The FOA is described as being paired with a companion funding opportunity (PAR-19-XXX) that targets basic mechanisms of aging using animal models. NIH frames the two as complementary: human population studies identify real-world patterns and outcomes, while animal-model studies help explain underlying mechanistic pathways.
13) Is integration across human and animal-model findings part of NIH’s stated intention?
Yes. The description indicates NIH intends for findings across the two tracks to be integrated to link observed real-world impacts (for example, worsening frailty after displacement) with plausible mechanistic explanations (for example, stress-mediated biological aging).
14) What is the stated public health goal of the research supported by this FOA?
The public health goal is practical: to improve the health and well-being of older adults by generating evidence that can inform disaster planning and resilience building, including preparedness, response, and recovery strategies tailored to older adults.
15) Does NIH want studies that only document harm, or also studies that identify solutions?
The emphasis on preparedness, response, and recovery suggests NIH is interested not only in documenting harm, but also in identifying modifiable factors and opportunities to reduce risk, support continuity of care, and speed functional and psychological recovery. The description also mentions interest in understanding which interventions, policies, community supports, or healthcare system practices help older adults fare better.
16) What activity categories are associated with this opportunity?
The activity categories listed span education, environment, and health, reflecting the cross-cutting nature of the topic.
17) Which CFDA numbers are associated with this opportunity?
The excerpt lists multiple CFDA numbers associated with the opportunity: 93.113, 93.307, 93.361, and 93.866.
18) Who is eligible to apply?
Eligibility is broad across U.S.-based institutions and organizations capable of conducting the proposed work. Eligible applicants include:
- State governments
- County, city, or township governments
- Special district governments
- Independent school districts
- Public and state-controlled institutions of higher education
- Private institutions of higher education
- Federally recognized Native American tribal governments
- Public housing authorities and Indian housing authorities
- Tribal organizations that are not federally recognized
- Nonprofits with or without 501(c)(3) status (outside higher education)
- For-profit organizations (other than small businesses)
- Small businesses
19) Does the announcement specifically mention institutions serving underrepresented populations?
Yes. The opportunity highlights inclusion of institutions and organizations such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities, and Tribally Controlled Colleges and Universities.
20) Are community-based or faith-based organizations included in eligible applicant types?
Yes. The excerpt explicitly mentions faith-based or community-based organizations among the groups highlighted for inclusion.
21) Are U.S. territories eligible or referenced?
Yes. The announcement highlights U.S. territories or possessions as included among the organizations referenced for participation.
22) Are eligible federal agencies included?
Yes. The excerpt mentions eligible federal agencies among the highlighted applicant categories.
23) Are foreign (non-U.S.) organizations eligible to apply?
No. The excerpt states that non-domestic (non-U.S.) entities and foreign institutions are not eligible to apply.
24) Can a U.S. organization apply if the project includes a non-domestic component?
No. The excerpt states that non-domestic components of U.S. organizations are not eligible.
25) Are “foreign components” allowed under NIH policy for this FOA?
No. The excerpt states that foreign components (as NIH defines them in its Grants Policy Statement) are not allowed.
26) When was this funding opportunity created?
The administrative details indicate the opportunity was created on 2019-04-11.
27) What closing date is listed in the provided information?
The excerpt lists an original closing date of 2021-03-08.
28) Is the award ceiling specified in the provided information?
No. The excerpt states that the award ceiling is not specified in the provided information.
29) Is the number of expected awards specified in the provided information?
No. The excerpt indicates the expected awards field is not specified in the provided information.
30) What kind of overall approach does NIH seem to encourage for this topic?
The opportunity is geared toward rigorous, multidisciplinary research connecting environmental extremes and disasters to the short- and long-term realities of aging, with an expectation that results will translate into knowledge that can improve preparedness, response, and recovery for older adults facing increasingly frequent and severe events.
Browse more opportunities from the same category: Education, Environment, Health
Next opportunity: Stimulating Innovations in Behavioral Intervention Research for Cancer Prevention and Control (R21 Clinical Trial Optional)
Previous opportunity: SMALL GRANTS FOR CONTENT PRODUCTION
Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for PAR 19 250
Applicants also applied for:
Applicants who have applied for this opportunity (PAR 19 250) also looked into and applied for these:
| Funding Opportunity |
|---|
| Basic and Translational Research on Adducts in Cancer Risk Identification and Prevention (R01 Clinical Trial Optional) Apply for PAR 19 251 Funding Number: PAR 19 251 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Dissemination and Implementation Research in Health (R21 Clinical Trial Optional) Apply for PAR 19 275 Funding Number: PAR 19 275 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $200,000 |
| Mechanism for Time-Sensitive Research Opportunities in Environmental Health Sciences (R21 Clinical Trial Not Allowed) Apply for RFA ES 19 011 Funding Number: RFA ES 19 011 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $200,000 |
| The Intersection of Sex and Gender Influences on Health and Disease (R01 Clinical Trial Optional) Apply for RFA OD 19 029 Funding Number: RFA OD 19 029 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Development of Highly Innovative Tools and Technology for Analysis of Single Cells (SBIR) (R43/R44 Clinical Trial Not Allowed) Apply for PA 20 047 Funding Number: PA 20 047 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Development of Highly Innovative Tools and Technology for Analysis of Single Cells (STTR) (R41/R42 Clinical Trial Not Allowed) Apply for PA 20 025 Funding Number: PA 20 025 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Biomedical Data Repository (U24 - Clinical Trials Not Allowed) Apply for PAR 20 089 Funding Number: PAR 20 089 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Biomedical Knowledgebase (U24 - Clinical Trials Not Allowed) Apply for PAR 20 097 Funding Number: PAR 20 097 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Research on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) (R01 Clinical Trials Not Allowed) Apply for PAR 20 165 Funding Number: PAR 20 165 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Research on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) (R21 Clinical Trials Not Allowed) Apply for PAR 20 168 Funding Number: PAR 20 168 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $200,000 |
| Independent Scientist Award (Parent K02 - Independent Clinical Trial Not Allowed) Apply for PA 20 174 Funding Number: PA 20 174 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Independent Scientist Award (Parent K02 - Independent Clinical Trial Required) Apply for PA 20 171 Funding Number: PA 20 171 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Independent Scientist Award (Parent K02 Independent Basic Experimental Studies with Humans Required) Apply for PA 20 173 Funding Number: PA 20 173 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Superfund Research Program Occupational Health and Safety Education Programs on Emerging Technologies (R25 - Clinical Trial Not Allowed) Apply for RFA ES 20 011 Funding Number: RFA ES 20 011 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $250,000 |
| Midcareer Investigator Award in Patient-Oriented Research (Parent K24 Independent Clinical Trial Not Allowed) Apply for PA 20 186 Funding Number: PA 20 186 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Midcareer Investigator Award in Patient-Oriented Research (Parent K24 - Independent Basic Experimental Studies with Humans Required) Apply for PA 20 192 Funding Number: PA 20 192 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Midcareer Investigator Award in Patient-Oriented Research (Parent K24 Independent Clinical Trial Required) Apply for PA 20 193 Funding Number: PA 20 193 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| NIH Exploratory/Developmental Research Grant Program (Parent R21 Basic Experimental Studies with Humans Required) Apply for PA 20 196 Funding Number: PA 20 196 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Required) Apply for PA 20 194 Funding Number: PA 20 194 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Not Allowed) Apply for PA 20 195 Funding Number: PA 20 195 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Inside Our Applicants Portal
Access Applicants Portal
- Grants Repository - Access current and historic funding opportunities with ease. Thousands of funding opportunities are published every week. We can help you sort through the database and find the eligible ones to apply for.
- Applicant Video Guides - The grant application process can be challenging to follow. We can help you with intuitive video guides to speed up the process and eliminate errors in submissions.
- Grant Proposal Wizard - We have developed a network of private funding organizations and investors across the United States. We can reach out and submit your proposal to these contacts to maximize your chances of getting the funding you need.
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Learn More
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "PAR 19 250", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.