Opportunity Information: Apply for EPA G2019 STAR D1
The U.S. Environmental Protection Agency (EPA) is offering a discretionary research grant through its Science to Achieve Results (STAR) program titled "Advancing Toxicokinetics for Efficient and Robust Chemical Evaluations." The core purpose of this opportunity is to fund projects that move toxicokinetic science forward in ways that make chemical safety evaluations more broadly usable, more reliable, and easier to apply in real decision-making contexts. The solicitation puts special emphasis on integrating toxicokinetic methods into New Approach Methodology (NAM) frameworks, meaning modern, often non-animal approaches that rely heavily on in vitro assays, computational models, and other alternative testing strategies.
At the center of the grant is toxicokinetics, the study of how chemicals enter and move through the body and what happens to them over time, including absorption, distribution, metabolism, and excretion (often summarized as ADME). EPA highlights toxicokinetics as a practical bridge between what researchers observe in simplified test systems (like cell-based in vitro experiments) and what regulators ultimately need to understand (the in vivo dose levels that could cause harm in people or ecological receptors). In plain terms, many NAM tools can tell you a concentration that triggers a biological change in cells, but regulators need to translate that into an external dose or exposure level that would produce a comparable internal concentration in an organism. The agency is seeking research that strengthens this translation process, improves how predictive these conversions are, reduces uncertainty in the extrapolations, and increases confidence that the results can be used in chemical evaluations.
The opportunity is designed for projects that develop or advance toxicokinetic tools, methods, or approaches that can be applied across a wider range of chemicals and evaluation scenarios. That includes improving the scientific and technical underpinnings that allow in vitro-derived bioactivity concentrations to be interpreted in an exposure and risk context. EPA signals that proposals should focus on making these tools more robust and broadly applicable rather than limited to narrow proof-of-concept cases, and that the end goal is better performance and credibility when toxicokinetic methods are used as part of NAM-based assessment workflows. The description also implies interest in innovations that increase predictivity, reduce uncertainty, and support more consistent use of toxicokinetic extrapolations in regulatory contexts.
From a funding and administrative standpoint, this is a grant (not a contract) under CFDA 66.509 in the environmental funding activity area. The funding opportunity number is EPA G2019 STAR D1. EPA anticipated making about five awards, with an award ceiling of $800,000 per award. The opportunity was posted on July 25, 2019, with an original closing date of September 10, 2019, while also noting that applicants should consult Section IV of the official solicitation for the definitive deadline details. Eligibility is listed broadly as "Others," with further clarification expected in the solicitation section titled "Additional Information on Eligibility," which typically means interested parties must verify their organizational type and any restrictions in the full announcement.
Overall, the grant aims to strengthen the toxicokinetic foundations needed to make NAM-based chemical evaluations more efficient and scientifically defensible, particularly by improving the tools used to translate in vitro bioactivity signals into meaningful in vivo dose or exposure metrics. By funding advancements in toxicokinetics that support these extrapolations, EPA is signaling a priority to modernize chemical assessment approaches while increasing confidence, transparency, and reliability in the resulting evaluations.Apply for EPA G2019 STAR D1
- The Environmental Protection Agency in the environment sector is offering a public funding opportunity titled "ADVANCING TOXICOKINETICS FOR EFFICIENT AND ROBUST CHEMICAL EVALUATIONS" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 66.509.
- This funding opportunity was created on Jul 25, 2019.
- Applicants must submit their applications by Sep 10, 2019 See Section IV of the solicitation for close date information.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $800,000.00 in funding.
- The number of recipients for this funding is limited to 5 candidate(s).
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Frequently Asked Questions (FAQs)
What is the name of this EPA funding opportunity?
The opportunity is titled "Advancing Toxicokinetics for Efficient and Robust Chemical Evaluations" under the U.S. Environmental Protection Agency (EPA) Science to Achieve Results (STAR) program.
What type of funding is this?
This is a discretionary research grant (not a contract) offered by EPA through the STAR program.
What is the main purpose of the grant?
The core purpose is to fund research that advances toxicokinetic science in ways that make chemical safety evaluations more broadly usable, more reliable, and easier to apply in real decision-making contexts.
What specific scientific area is the grant focused on?
The focus is toxicokinetics, including how chemicals enter and move through the body over time, commonly summarized as ADME: absorption, distribution, metabolism, and excretion.
Why is EPA emphasizing toxicokinetics in this solicitation?
EPA highlights toxicokinetics as a practical bridge between simplified test systems (like in vitro cell-based experiments) and the in vivo dose or exposure levels regulators need to evaluate potential harm in people or ecological receptors.
How does this opportunity relate to New Approach Methodologies (NAMs)?
The solicitation places special emphasis on integrating toxicokinetic methods into NAM frameworks. NAMs are modern approaches that often rely on in vitro assays, computational models, and other alternative testing strategies, frequently designed to reduce reliance on traditional animal testing.
What problem is EPA trying to solve with this research?
Many NAM tools can identify a concentration that triggers a biological change in cells, but regulators need to translate that into an external dose or exposure level that would produce a comparable internal concentration in an organism. EPA is seeking research that strengthens and improves that translation process.
What kinds of outcomes is EPA looking for in proposed projects?
EPA is looking for advancements that improve predictivity, reduce uncertainty in extrapolations, and increase confidence that toxicokinetic-based conversions can be used in chemical evaluations and regulatory contexts.
What types of projects are encouraged under this grant?
Projects that develop or advance toxicokinetic tools, methods, or approaches that can be applied across a wider range of chemicals and evaluation scenarios, including improvements that help interpret in vitro-derived bioactivity concentrations in an exposure and risk context.
Does EPA want narrow proof-of-concept studies or broadly applicable tools?
The description signals a preference for tools and approaches that are robust and broadly applicable rather than limited to narrow proof-of-concept cases.
How does this grant support chemical evaluation workflows?
The goal is to strengthen toxicokinetic foundations so NAM-based chemical evaluations become more efficient and scientifically defensible, with better performance and credibility when toxicokinetic methods are used within NAM-based assessment workflows.
What is the funding opportunity number?
The funding opportunity number is EPA G2019 STAR D1.
What is the CFDA number for this opportunity?
The CFDA number listed is 66.509.
What is the funding activity area?
The opportunity is listed under the environmental funding activity area.
How many awards does EPA expect to make?
EPA anticipated making about five awards.
What is the maximum award amount (award ceiling)?
The award ceiling is $800,000 per award.
When was the opportunity posted?
The opportunity was posted on July 25, 2019.
What is the closing date for applications?
The original closing date noted is September 10, 2019. The announcement also indicates applicants should consult Section IV of the official solicitation for definitive deadline details.
Who is eligible to apply?
Eligibility is listed broadly as "Others." Additional clarification is expected in the solicitation section titled "Additional Information on Eligibility," meaning applicants should verify their organizational type and any restrictions in the full announcement.
Where should applicants look for the definitive deadline and eligibility details?
The announcement specifically points applicants to Section IV of the official solicitation for definitive deadline details, and to the solicitation section titled "Additional Information on Eligibility" for eligibility clarification.
What does EPA mean by translating in vitro bioactivity to in vivo dose or exposure?
It refers to improving the scientific basis for converting concentrations that produce effects in in vitro systems into estimates of the external dose or exposure that would lead to similar internal concentrations in an organism, which is a key step for making NAM outputs usable in chemical evaluations.
What broader impact is EPA aiming for with this solicitation?
EPA is signaling a priority to modernize chemical assessment approaches by strengthening toxicokinetics that support NAM-based extrapolations, with an emphasis on increasing confidence, transparency, reliability, and consistency in resulting evaluations.
Browse more opportunities from the same category: Environment
Next opportunity: Species Recovery Grants to Tribes
Previous opportunity: OVC FY 2019 Project Beacon: Increasing Services for Urban American Indian and Alaska Native Victims of Sex Trafficking
Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for EPA G2019 STAR D1
Applicants also applied for:
Applicants who have applied for this opportunity (EPA G2019 STAR D1) also looked into and applied for these:
| Funding Opportunity |
|---|
| SUSTAINABLE MATERIALS MANAGEMENT GRANTS Apply for EPA SMMS 2019 1 Funding Number: EPA SMMS 2019 1 Agency: Environmental Protection Agency Category: Environment Funding Amount: $100,000 |
| Contaminated Sites, Natural Disasters, Changing Environmental Conditions and Vulnerable Communities: Research to Build Resilience Apply for EPA G2019 STAR E1 Funding Number: EPA G2019 STAR E1 Agency: Environmental Protection Agency Category: Environment Funding Amount: $800,000 |
| Interpretive and Outdoor Recreational Programs Apply for NPS 19 NERO 0084 Funding Number: NPS 19 NERO 0084 Agency: Department of the Interior, National Park Service Category: Environment Funding Amount: $37,645 |
| Training for Improved Protection of Drinking Water Sources Apply for EPA OW OGWDW 19 02 Funding Number: EPA OW OGWDW 19 02 Agency: Environmental Protection Agency Category: Environment Funding Amount: $900,000 |
| Notice of Intent Apply for USGS 19 FAC 0314 Funding Number: USGS 19 FAC 0314 Agency: Department of the Interior, U. S. Geological Survey Category: Environment Funding Amount: $50,000 |
| 15.678 Apply for F19AS00327 Funding Number: F19AS00327 Agency: Department of the Interior, Fish and Wildlife Service Category: Environment Funding Amount: $249,305 |
| Tribal Training Support for the Community and Tribal Air Quality Programs Apply for EPA OAR OAQPS 19 06 Funding Number: EPA OAR OAQPS 19 06 Agency: Environmental Protection Agency Category: Environment Funding Amount: $300,000 |
| Document and Assess Condition of Historic Structures Associated with the Old Natchez Trace: Mount Locust and the Gordon House Apply for NPS NOI 19 1092 Funding Number: NPS NOI 19 1092 Agency: Department of the Interior, National Park Service Category: Environment Funding Amount: $30,000 |
| Notice of Intent Relationships of feeding ecology and contaminant Apply for USGS 19 FAC 0335 Funding Number: USGS 19 FAC 0335 Agency: Department of the Interior, U. S. Geological Survey Category: Environment Funding Amount: $50,000 |
| Expansion of LandScope Chesapeake Apply for NPS 19 NERO 0092 Funding Number: NPS 19 NERO 0092 Agency: Department of the Interior, National Park Service Category: Environment Funding Amount: $65,000 |
| Mapping Illicit Supply Networks to Combat Conservation Crimes at their Convergence Apply for SFOP0006106 Funding Number: SFOP0006106 Agency: Department of State, Bureau of Oceans - Int. Environmental - Scientific Category: Environment Funding Amount: $1,137,500 |
| National Farmworker Training Program Apply for EPA HQ OPP 2019 004 Funding Number: EPA HQ OPP 2019 004 Agency: Environmental Protection Agency Category: Environment Funding Amount: $2,500,000 |
| Connecting People to the Historic and Natural Resources of the James River Apply for NPS 19 NERO 0098 Funding Number: NPS 19 NERO 0098 Agency: Department of the Interior, National Park Service Category: Environment Funding Amount: $208,835 |
| Upper Coosa Habitat Restoration Apply for F19AS00334 Funding Number: F19AS00334 Agency: Department of the Interior, Fish and Wildlife Service Category: Environment Funding Amount: Case Dependent |
| Planning, Educational, and Recreational Initiatives at SEF Apply for NPS 19 NERO 0101 Funding Number: NPS 19 NERO 0101 Agency: Department of the Interior, National Park Service Category: Environment Funding Amount: $82,105 |
| Clean Vessel Act Apply for F19AS00240 Funding Number: F19AS00240 Agency: Department of the Interior, Fish and Wildlife Service Category: Environment Funding Amount: $1,500,000 |
| Chesapeake Bay Program Office Fiscal Year 2019 Request for Applications for Chesapeake Bay Optimization Tool Development Apply for EPA R3 CBP 19 05 Funding Number: EPA R3 CBP 19 05 Agency: Environmental Protection Agency Category: Environment Funding Amount: $956,400 |
| New Jersey Pinelands Reserve Apply for NPS 19 NERO 0126 Funding Number: NPS 19 NERO 0126 Agency: Department of the Interior, National Park Service Category: Environment Funding Amount: $1,500,000 |
| Ducks Unlimited Black Rail Initiative Apply for F19AS00347 Funding Number: F19AS00347 Agency: Department of the Interior, Fish and Wildlife Service Category: Environment Funding Amount: Case Dependent |
| Notice of Intent to Award to Colorado River Indian Tribe Apply for BOR LC 19 N029 Funding Number: BOR LC 19 N029 Agency: Department of the Interior, Bureau of Reclamation Category: Environment Funding Amount: $400,000 |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Inside Our Applicants Portal
Access Applicants Portal
- Grants Repository - Access current and historic funding opportunities with ease. Thousands of funding opportunities are published every week. We can help you sort through the database and find the eligible ones to apply for.
- Applicant Video Guides - The grant application process can be challenging to follow. We can help you with intuitive video guides to speed up the process and eliminate errors in submissions.
- Grant Proposal Wizard - We have developed a network of private funding organizations and investors across the United States. We can reach out and submit your proposal to these contacts to maximize your chances of getting the funding you need.
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Learn More
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "EPA G2019 STAR D1", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.