Opportunity Information: Apply for EPA G2019 STAR D1
The U.S. Environmental Protection Agency (EPA) is offering a discretionary research grant through its Science to Achieve Results (STAR) program titled "Advancing Toxicokinetics for Efficient and Robust Chemical Evaluations." The core purpose of this opportunity is to fund projects that move toxicokinetic science forward in ways that make chemical safety evaluations more broadly usable, more reliable, and easier to apply in real decision-making contexts. The solicitation puts special emphasis on integrating toxicokinetic methods into New Approach Methodology (NAM) frameworks, meaning modern, often non-animal approaches that rely heavily on in vitro assays, computational models, and other alternative testing strategies.
At the center of the grant is toxicokinetics, the study of how chemicals enter and move through the body and what happens to them over time, including absorption, distribution, metabolism, and excretion (often summarized as ADME). EPA highlights toxicokinetics as a practical bridge between what researchers observe in simplified test systems (like cell-based in vitro experiments) and what regulators ultimately need to understand (the in vivo dose levels that could cause harm in people or ecological receptors). In plain terms, many NAM tools can tell you a concentration that triggers a biological change in cells, but regulators need to translate that into an external dose or exposure level that would produce a comparable internal concentration in an organism. The agency is seeking research that strengthens this translation process, improves how predictive these conversions are, reduces uncertainty in the extrapolations, and increases confidence that the results can be used in chemical evaluations.
The opportunity is designed for projects that develop or advance toxicokinetic tools, methods, or approaches that can be applied across a wider range of chemicals and evaluation scenarios. That includes improving the scientific and technical underpinnings that allow in vitro-derived bioactivity concentrations to be interpreted in an exposure and risk context. EPA signals that proposals should focus on making these tools more robust and broadly applicable rather than limited to narrow proof-of-concept cases, and that the end goal is better performance and credibility when toxicokinetic methods are used as part of NAM-based assessment workflows. The description also implies interest in innovations that increase predictivity, reduce uncertainty, and support more consistent use of toxicokinetic extrapolations in regulatory contexts.
From a funding and administrative standpoint, this is a grant (not a contract) under CFDA 66.509 in the environmental funding activity area. The funding opportunity number is EPA G2019 STAR D1. EPA anticipated making about five awards, with an award ceiling of $800,000 per award. The opportunity was posted on July 25, 2019, with an original closing date of September 10, 2019, while also noting that applicants should consult Section IV of the official solicitation for the definitive deadline details. Eligibility is listed broadly as "Others," with further clarification expected in the solicitation section titled "Additional Information on Eligibility," which typically means interested parties must verify their organizational type and any restrictions in the full announcement.
Overall, the grant aims to strengthen the toxicokinetic foundations needed to make NAM-based chemical evaluations more efficient and scientifically defensible, particularly by improving the tools used to translate in vitro bioactivity signals into meaningful in vivo dose or exposure metrics. By funding advancements in toxicokinetics that support these extrapolations, EPA is signaling a priority to modernize chemical assessment approaches while increasing confidence, transparency, and reliability in the resulting evaluations.Apply for EPA G2019 STAR D1
- The Environmental Protection Agency in the environment sector is offering a public funding opportunity titled "ADVANCING TOXICOKINETICS FOR EFFICIENT AND ROBUST CHEMICAL EVALUATIONS" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 66.509.
- This funding opportunity was created on Jul 25, 2019.
- Applicants must submit their applications by Sep 10, 2019 See Section IV of the solicitation for close date information.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $800,000.00 in funding.
- The number of recipients for this funding is limited to 5 candidate(s).
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
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