Opportunity Information: Apply for CDC RFA GH20 2045
The CDC funding opportunity CDC RFA GH20-2045, titled "Accelerating Lesotho's Progress to Epidemic Control Through Health System Strengthening and Delivery of Comprehensive HIV/TB Care, Treatment and Prevention Services under PEPFAR," is a discretionary cooperative agreement designed to support Lesotho in reaching and sustaining HIV epidemic control while also addressing the country's heavy tuberculosis burden. The program is grounded in the reality that Lesotho faces one of the most severe HIV epidemics globally, with HIV prevalence estimated at 25.6 percent among people ages 15 to 59 and an adult annual HIV incidence of about 1.1 percent in the same age group. At the same time, TB remains a major public health threat, with an estimated 15,000 TB cases each year. The overall intent is to maximize health impact by expanding access to proven HIV and TB interventions, reducing new infections, and lowering illness and deaths related to HIV and TB, while building stronger systems that can sustain progress over time.
Financially, the notice anticipates approximately $16,000,000 in total funding for Year 1, dependent on the availability of funds, with one expected award. The listing notes an "Award Ceiling for Year 1 is 0 (none)," which can appear contradictory, but in practice typically indicates that CDC did not set a per-award cap in the announcement even though it provided an estimated total funding amount for the first year. The instrument type is a cooperative agreement, meaning CDC expects substantial involvement in the project’s implementation through technical collaboration, monitoring, and shared oversight, rather than simply issuing funds with minimal federal engagement.
Programmatically, the opportunity focuses on scaling up comprehensive, high-quality, evidence-based HIV and TB prevention, care, and treatment services across Lesotho in a way that aligns with the country’s national HIV and TB implementation plans. Key HIV priorities include expanding HIV case identification and ensuring same-day linkage to antiretroviral therapy (ART) so people who test positive can start treatment quickly, which is critical for both individual health and reducing onward transmission. The NOFO also emphasizes prevention of mother-to-child transmission (PMTCT), aiming to protect infants from HIV while improving maternal outcomes through testing, treatment, and retention in care. On the TB side, it supports TB prevention, diagnosis, and clinical management integrated with HIV services, reflecting the close connection between the two diseases and the importance of coordinated care in high-burden settings.
A central strategy running through the announcement is health system strengthening, particularly boosting the Ministry of Health’s capacity to implement and manage HIV and TB programs in supported facilities. Rather than operating as a stand-alone service delivery project, the award is structured to help the Government of Lesotho identify and fix system-level barriers and operational bottlenecks that slow progress. This includes strengthening program management, improving service delivery quality, and building more reliable systems that can maintain coverage and performance as the country pushes toward the global 95-95-95 targets (95 percent of people living with HIV know their status, 95 percent of those diagnosed receive sustained ART, and 95 percent of those on ART achieve viral suppression). The expectation is that stronger facility-level and national systems will make HIV and TB services more consistent, scalable, and resilient, supporting long-term epidemic control.
In terms of eligibility and administration, the opportunity was open to unrestricted applicants (meaning any entity type could apply, subject to any additional eligibility clarifications within the full notice). The funding falls under the Department of Health and Human Services, Centers for Disease Control and Prevention, Center for Global Health, with CFDA number 93.067. The NOFO was created on January 8, 2020, with an original closing date of March 8, 2020, and electronic submissions due by 11:59 p.m. Eastern Time on the deadline date. Overall, the opportunity is best understood as a large-scale PEPFAR-aligned effort to accelerate Lesotho’s path to epidemic control by expanding core HIV/TB services while simultaneously strengthening the health system structures needed to sustain and manage those services effectively.Apply for CDC RFA GH20 2045
- The Department of Health and Human Services, Centers for Disease Control - CGH in the health sector is offering a public funding opportunity titled "Accelerating Lesotho's Progress to Epidemic Control Through Health System Strengthening and Delivery of Comprehensive HIV/TB Care, Treatment and Prevention Services under the President's Emergency Plan for AIDS Relief (PEPFAR)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.067.
- This funding opportunity was created on Jan 08, 2020.
- Applicants must submit their applications by Mar 08, 2020 Electronically submitted applications must be submitted no later than 1159 p.m., ET, on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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